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Early Emphysema in Patients with Anorexia Nervosa

 
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PostPosted: Thu Jun 15, 2006 6:36 pm    Post subject: Early Emphysema in Patients with Anorexia Nervosa
 
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Postmortem studies of patients who died in the Warsaw Ghetto during World War II suggested that death from starvation was associated with pulmonary emphysema. This study re-examines this hypothesis in patients who are chronically malnourished because of anorexia nervosa. Age, smoking history, body mass index, and pulmonary function were measured in 21 subjects with anorexia nervosa and 16 control subjects. Computed tomography (CT) scans were obtained from three regions of the lung (at the level of the aortic arch, the carina, and the posterior position of the eighth rib) using a multislice scanner. The CT measurements of lung density, emphysema, and surface area-to-volume ratio were obtained using the X-ray attenuation values. CT measurements of emphysemawere greater in the group that was anorexic than in historical control subjects (p  0.001). Furthermore, there were significant correlations between the bodymass index and the CT measures of emphysema for all the patients and between diffusing capacity and the CT measurements in the patients who were anorexic.


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